Although specific drug interaction studies have not been conducted with ALPHAGAN® P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Timolol maleate is a beta 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Alphagan P It has a peak ocular hypotensive effect occurring at two hours post-dosing. Patients also should be advised that if they have ocular surgery or develop an intercurrent ocular condition (e.g., trauma or infection), they should immediately seek their physician's advice concerning the continued use of the present multidose container. The following reactions have been identified during postmarketing use of brimonidine tartrate ophthalmic solutions in clinical practice. Specifically, pharmacists have access to drug information from a … Fluorophotometric studies in animals and humans suggest that brimonidine tartrate has a dual mechanism of action. mechanism of action Brimonidine is a potent alpha-2 adrenergic receptor agonist that shows up to 1,700-fold selectivity for alpha-2 receptors over alpha-1 receptors. Brimonidine tartrate was not teratogenic when given orally during gestation days 6 through 15 in rats and days 6 through 18 in rabbits. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to brimonidine tartrate ophthalmic solutions, or a combination of these factors, include: bradycardia, depression, hypersensitivity, iritis, keratoconjunctivitis sicca, miosis, nausea, skin reactions (including erythema, eyelid pruritus, rash, and vasodilation), syncope, and tachycardia. Patients who engage in hazardous activities should be cautioned of the potential for a decrease in mental alertness. 0.15% This loss of effect appears with a variable time of onset in each patient and should be closely monitored. ALPHAGAN® P (brimonidine tartrate ophthalmic solution) 0.1% or 0.15%, sterile, is a relatively selective alpha-2 adrenergic receptor agonist (topical intraocular pressure lowering agent). What else should I know about brimonidine? Which Specialist Is Right for You, When Popping Champagne Watch Out for That Cork, Cataract Surgery in Infancy Raise Glaucoma Risk, COVID Tied to Rare But Severe Eye Infection. Given the similar IOP-lowering efficacy of the 2 compounds, this finding is consistent with a non-IOP-related mechanism of action favoring brimonidine-treated patients. In this type of glaucoma, too much fluid (aqueous humor) is made within the eye and causes high pressures within the eye. Upon ocular administration, brimonidine acts on the blood vessels causing them to constrict which leads to a … ophthalmic solution) If untreated, glaucoma may damage the optic nerve and other parts of the eye, causing the loss of vision or even blindness. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication. In solution, ALPHAGAN® P (brimonidine tartrate ophthalmic solution) has a clear, greenish-yellow color. New Window. Available for Android and iOS devices. ALPHAGAN ® eye drops, including how to use the eye drops. ALPHAGAN® P has not been studied in patients with hepatic impairment. Brimonidine is an imidazole derivative and a selective alpha-2 adrenergic receptor agonist. No compound-related carcinogenic effects were observed in either mice or rats following a 21-month and 24-month study, respectively. 0.1% CLINICAL PHARMACOLOGY Mechanism of action: ALPHAGANP is a relatively selective alpha-2- adrenergic receptor agonist with a peak ocular hypotensive effect occurring at two hours post-dosing. , 0.15 % ) or 6.9-7.4 ( 0.15 %, and how does it work ( mechanism of action rises! Tartrate was not teratogenic when given orally during gestation days 6 through 15 in rats and days through! As 0.1 %, 0.15 %, and 0.2 % solution of ALPHAGAN… Alphagan ophthalmic drops including. Generic name: brimonidine tartrate ophthalmic solutions in CLINICAL practice effects of prescription drugs, are as... 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